| TOP LATINO SEMANA 21 – 2016 |
| ES | SA | 2S | 3S | Artista | Canción | SS | PA | Sello |
| 1 | 1 | 2 | 1 | Rihanna Feat. Drake | Work | 14 | 1 (4) | UNIVERSAL MUSIC |
| 2 | 9 | 12 | 29 | Chino & Nacho Feat. Daddy Yankee | Andas en mi cabeza | 6 | 2 | MACHETE |
| 3 | 2 | 1 | 3 | Nicky Jam | Hasta el amanecer | 15 | 1 | SONY MUSIC |
| 4 | 4 | 9 | 12 | Mike Posner | I took a pill in ibiza | 7 | 4 | UNIVERSAL MUSIC |
| 5 | 14 | 22 | NI | Enrique Iglesias Feat. Wisin | Duele el corazon | 3 | 5 | SONY MUSIC |
| 6 | 5 | 3 | 2 | Alan Walker | Faded | 14 | 2 | SONY MUSIC |
| 7 | 6 | 24 | 26 | Dj Snake Feat. Bipolar Shunshine | Middle | 11 | 6 | WARNER MUSIC |
| 8 | 12 | 4 | 4 | Sia Feat. Jean Paul | Cheap thrills | 9 | 4 (2) | SONY MUSIC |
| 9 | 7 | 6 | 7 | Joey Montana | Picky | 16 | 5 | UNIVERSAL MUSIC |
| 10 | 8 | 5 | 5 | Major Lazer Feat. Nyla & Fuse ODG | Light it up | 15 | 5 | WARNER MUSIC |
| 11 | 18 | 25 | 22 | Meghan Trainor | No | 5 | 11 | EPIC |
| 12 | 3 | 8 | 10 | Farruko | Obsesionado | 14 | 3 | INDEPENDIENTE |
| 13 | 11 | 13 | 11 | DNCE | Cake by the ocean | 12 | 10 | REPUBLIC |
| 14 | 10 | 14 | 14 | Twenty One Pilots | Stressed out | 13 | 2 | FUELED BY RAMEN/RRP |
| 15 | 15 | 16 | 17 | Likas Graham | 7 years | 9 | 5 | WARNER MUSIC |
| 16 | 16 | 11 | 9 | Justin Bieber | Love yourself | 16 | 1 | UNIVERSAL MUSIC |
| 17 | 21 | 23 | 28 | Jonas Blue Feat. Dakota | Fast car | 11 | 17 | UNIVERSAL MUSIC |
| 18 | 27 | 21 | 21 | La Adictiva | Te diran | 4 | 18 | ANVAL MUSIC |
| 19 | 23 | 28 | NI | Fifth Harmony Feat. Ty Dolla Sign | Work from home | 3 | 19 | SYCO/EPIC |
| 20 | 29 | 30 | 24 | Thalia Feat. Maluma | Desde esa noche | 8 | 20 | SONY MUSIC |
| 21 | 20 | 17 | 16 | Coldplay | Adventure of a lifetime | 16 | 6 (2) | WARNER MUSIC |
| 22 | 28 | 26 | 27 | Coldplay | Hymn for the weekend | 12 | 21 | WARNER MUSIC |
| 23 | 25 | 15 | 6 | David Guetta Feat. Sia & Fetty Wap | Bang my head | 16 | 3 (2) | WARNER MUSIC |
| 24 | 24 | 19 | 18 | Zayn | Pillowtalk | 11 | 13 | SONY MUSIC |
| 25 | NI | Ozuna Feat. Arcangel & Farruko | Si no te quiere | 1 | 25 | INDEPENDIENTE |
| 26 | 39 | NI | | Drake Feat. Wizkid & Kyla | One dance | 2 | 26 | YMCMB/REPUBLIC |
| 27 | 30 | 10 | 13 | Maluma | El perdedor | 7 | 10 | SONY MUSIC |
| 28 | 38 | 36 | 31 | Gente De Zona Feat. Marc Anthony | Traidora | 16 | 11 | SONY MUSIC |
| 29 | 33 | 31 | 32 | Zara Larsson | Lush life | 8 | 29 | SONY MUSIC |
| 30 | 32 | RI | 25 | G-Eazy & Bebe Rexha | Me, myself & I | 6 | 21 | SONY MUSIC |
| 31 | 19 | 29 | 20 | Yandel | Encantadora | 16 | 10 | UNIVERSAL MUSIC |
| 32 | 26 | 20 | 15 | Justin Bieber Feat. J Balvin | Sorry | 16 | 1 (4) | UNIVERSAL MUSIC |
| 33 | RI | Pipe Peláez y Manuel Julián | Vestirte de amor | 3 | 19 | SONY MUSIC |
| 34 | RI | 34 | 35 | Gustavo Elis Feat. Oscarcito | Mujer de mi vida | 4 | 34 | 311 GROUP |
| 35 | 36 | NI | | Banda Los Recoridos | Me esta gustando | 2 | 35 | UMLE/DISA |
| 36 | 22 | 7 | 8 | Jesse & Joy Feat. Alejandro Sanz | No soy una de esas | 16 | 2 | WARNER MUSIC |
| 37 | 31 | 18 | 19 | Matt Simons | Catch & release | 12 | 12 | PIAS |
| 38 | RI | 30 | Flo Rida | My house | 9 | 20 | ATLANTIC |
| 39 | 13 | RI | 38 | Zion & Lennox | Embriágame | 4 | 13 | WARNER LATINA |
| 40 | 34 | NI | | Cnco | Tan facil | 2 | 34 | SONY MUSIC |
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| | | | | SALIERON | | | | |
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| | 17 | NI | | 99 Souls Feat. Destiny’S Child & Brandy | The girl is mine | 1 | 17 | SONY MUSIC |
| | 35 | NI | | Tico & Javi | Te voy a querer | 1 | 35 | INDEPENDIENTE |
| | 37 | 32 | 33 | Shawn Mendes | Stitches | 15 | 10 | UNIVERSAL MUSIC |
| | 40 | 33 | 23 | Charly Black | Gyal you a party animal | 4 | 22 | INDEPENDIENTE |
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| | | | | LA GRAN CAÍDA | | | | |
| | | | | EL GRAN SALTO | | | 3S | HACE 3 SEMANAS |
| | | | | MÁS SEMANAS EN LISTA | | | SS | SEMANAS EN LISTA |
| | | | | INGRESO MAS ALTO | | | PA | POSICIÓN MAS ALTA |
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| | | | RI | REINGRESO | | | | |
| | | | NI | NUEVO INGRESO | | | | |
| | | | NI | NUEVO INGRESO | | | | |
