| TOP LATINO SEMANA 46 – 2010 |
| ES | SA | 2S | 3S | Canción | Artista | SS | PA | Distribuidor |
| 1 | 1 | 3 | 5 | Loca | Shakira ft Dizzie Rascal & El Cata | 7 | 1(2) | SONY MUSIC |
| 2 | 5 | 8 | 9 | Love the way you lie | Eminem & Rihanna | 13 | 2 | UNIVERSAL |
| 3 | 4 | 1 | 1 | Cuando me enamoro | Enrique Iglesias & Juan Luis Guerra | 25 | 1(15) | UNIVERSAL |
| 4 | 3 | 4 | 2 | We not speak americano | Yolanda Be Cool | 13 | 2(2) | INDEPENDIENTE |
| 5 | 2 | 5 | 3 | Danza kuduro | Don Omar | 8 | 2 | UNIVERSAL |
| 6 | 10 | 2 | 4 | Alejandro | Lady Gaga | 23 | 2 | UNIVERSAL |
| 7 | 6 | 10 | 8 | Teenage dream | Katty Perry | 6 | 6 | EMI |
| 8 | 8 | 7 | 10 | Club can’t handle me | Florida Ft David Guetta | 9 | 7 | WARNER |
| 9 | 9 | 13 | NI | Bésame | Camila | 3 | 9 | SONY MUSIC |
| 10 | 13 | 16 | 13 | Estoy enamorado | Wisin & Yandel | 9 | 10 | INDEPENDIENTE |
| 11 | 12 | 11 | 22 | Dj got us fallin in love | Usher Feat. Pitbull | 4 | 11 | SONY MUSIC |
| 12 | 7 | 6 | 7 | I like it | Enrique Iglesias & Pitbull | 18 | 6 | UNIVERSAL |
| 13 | 15 | 15 | 14 | La despedida | Daddy Yankee | 11 | 13 | UNIVERSAL |
| 14 | 14 | 14 | 21 | Prohibido quererme | Ov7 | 4 | 14 | SONY MUSIC |
| 15 | 11 | 9 | 11 | Somebody to love | Justin Bieber | 11 | 9 | UNIVERSAL |
| 16 | 20 | NI | Adrenalina | Luan Santana | 2 | 16 | SONY MUSIC |
| 17 | 17 | 17 | 23 | Dynamite | Taio Cruz | 6 | 17 | UNIVERSAL |
| 18 | 21 | 19 | 18 | Estoy enamorada | Thalia & Pedro Capo | 10 | 17 | SONY MUSIC |
| 19 | 28 | RI | Nada de más | Belanova | 3 | 19 | UNIVERSAL |
| 20 | 19 | 21 | 24 | Solo tuyo | Felipe Pelaez | 7 | 19 | SONY MUSIC |
| 21 | 22 | 20 | 15 | Estar contigo | Alex Ubago – Jorge Villamizar & Lena | 6 | 15 | WARNER |
| 22 | 33 | NI | Just the way you are | Bruno Mars | 2 | 22 | WARNER |
| 23 | 16 | 12 | 6 | Aléjate de mi | Camila | 26 | 2(9) | SONY MUSIC |
| 24 | 18 | 23 | NI | Corazon sin cara | Prince Royce | 3 | 18 | TOP STOP |
| 25 | 31 | NI | Only girl | Rihanna | 2 | 25 | UNIVERSAL |
| 26 | 32 | 30 | 31 | El malo | Aventura | 9 | 23 | PREMIUN LATIN MUSIC |
| 27 | 24 | 18 | 12 | Yerbatero | Juanes | 18 | 4 | UNIVERSAL |
| 28 | 35 | 32 | 32 | Y si te quedas que | Santiago Cruz | 5 | 28 | INDEPENDIENTE |
| 29 | 23 | 24 | 27 | Mi corazón se fue | Diego Torres | 6 | 23 | UNIVERSAL |
| 30 | 30 | 39 | RI | Tu angelito | Chino & Nacho | 5 | 30 | UNIVERSAL |
| 31 | 29 | 26 | 30 | Stereo love | Edward Maya Feat. Vika Jigulina Or Alicia | 28 | 10 | CAT MUSIC |
| 32 | 36 | NI | Quiere pa’ que te quieran | Dyland & Lenny | 2 | 32 | SONY MUSIC |
| 33 | NI | Como recobro mi vida | Reinaldo | 1 | 33 | INDEPENDIENTE |
| 34 | 34 | 28 | 19 | Labios de miel | Luis Miguel | 10 | 10 | WARNER |
| 35 | 27 | RI | Si no le contesto | Plan B | 2 | 27 | PINA RECORDS |
| 36 | 39 | 35 | 26 | Nuestro amor será leyenda | Alejandro Sanz | 19 | 13 | WARNER |
| 37 | NI | Dopamina | Belinda | 1 | 37 | EMI |
| 38 | NI | Y no regresas | Juanes | 1 | 38 | UNIVERSAL |
| 39 | 38 | 31 | 33 | 24 horas | David Bisbal | 9 | 17 | UNIVERSAL |
| 40 | NI | La calle | Juan Luis Guerra & Las 4:40 | 1 | 40 | CAPITOL |
| | | | SALIERON | | | | |
| 25 | RI | 16 | Tu voz | Erik Rubin | 2 | 16 | INDEPENDIENTE |
| 26 | RI | | Pensando en ti | M.Pizzolante, Servando & Florentino | 1 | 26 | INDEPENDIENTE |
| 37 | 22 | 17 | California gurls | Katty Perry | 19 | 4 | EMI |
| 40 | 27 | NI | 16 añitos | Dani Martin | 2 | 27 | SONY MUSIC |
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| | | | LA GRAN CAÍDA | | 2S | HACE 2 SEMANAS |
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| EL GRAN SALTO | | 3S | HACE 3 SEMANAS |
| | | | MÁS SEMANAS EN LISTA | | SS | SEMANAS EN LISTA |
| | | | INGRESO MAS ALTO | | PA | POSICIÓN MAS ALTA |
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| | | RI | REINGRESO | | |
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| | | NI | NUEVO INGRESO | | |
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