| TOP LATINO SEMANA 42 – 2010 |
| ES | SA | 2S | 3S | Canción | Artista | SS | PA | Distribuidor |
| 1 | 1 | 1 | 1 | Cuando me enamoro | Enrique Iglesias & Juan Luis Guerra | 21 | 1(13) | UNIVERSAL |
| 2 | 3 | 4 | 4 | We not speak americano | Yolanda Be Cool | 9 | 2 | INDEPENDIENTE |
| 3 | 2 | 2 | 2 | Aléjate de mi | Camila | 22 | 2(9) | SONY MUSIC |
| 4 | 4 | 3 | 3 | Alejandro | Lady Gaga | 19 | 3(8) | UNIVERSAL |
| 5 | 6 | 7 | 21 | Danza kuduro | Don Omar | 4 | 5 | UNIVERSAL |
| 6 | 10 | 8 | 8 | Love the way you lie | Eminem & Rihanna | 9 | 6 | UNIVERSAL |
| 7 | 5 | 5 | 5 | Yerbatero | Juanes | 14 | 4 | UNIVERSAL |
| 8 | 9 | 11 | 10 | Club can’t handle me | Florida Ft David Guetta | 5 | 8 | WARNER |
| 9 | 7 | 6 | 7 | I like it | Enrique Iglesias & Pitbull | 14 | 7 | UNIVERSAL |
| 10 | 13 | NI | Teenage dream | Katty Perry | 2 | 13 | EMI |
| 11 | 24 | 24 | 36 | Somebody to love | Justin Bieber | 7 | 11 | UNIVERSAL |
| 12 | 27 | 40 | NI | Loca | Shakira ft Dizzie Rascal & El Cata | 3 | 12 | SONY MUSIC |
| 13 | 12 | 16 | 17 | Estoy enamorado | Wisin & Yandel | 5 | 12 | INDEPENDIENTE |
| 14 | 14 | 15 | 26 | La despedida | Daddy Yankee | 7 | 14 | UNIVERSAL |
| 15 | 19 | 14 | 14 | Afortunadamente no eres tu | Paty Cantú | 7 | 14 | INDEPENDIENTE |
| 16 | 20 | 28 | NI | Não mais | Victor & Leo | 3 | 16 | SONY MUSIC |
| 17 | 22 | 21 | 24 | Estoy enamorada | Thalia & Pedro Capo | 6 | 17 | SONY MUSIC |
| 18 | 15 | 13 | 12 | California gurls | Katty Perry | 16 | 4 | EMI |
| 19 | 8 | 10 | 9 | Inevitable | Dulce María | 13 | 7 | EMI |
| 20 | 32 | 12 | 11 | All the lovers | Kylie Minogue | 15 | 10 | EMI |
| 21 | 21 | 22 | 16 | Nuestro amor será leyenda | Alejandro Sanz | 15 | 13 | WARNER |
| 22 | 25 | 20 | 20 | El doctorado | Tony Dize | 41 | 4 | PINA RECORDS |
| 23 | 26 | 25 | 13 | Labios de miel | Luis Miguel | 6 | 10 | WARNER |
| 24 | 28 | 31 | 32 | Sick of love | Robert Ramirez | 15 | 13 | INDEPENDIENTE |
| 25 | 23 | 23 | 22 | Stereo love | Edward Maya Feat. Vika Jigulina Or Alicia | 24 | 10 | CAT MUSIC |
| 26 | 17 | 18 | 25 | Mi amor es pobre | Tony Dize Feat. Kem – Y & Arcangel | 8 | 17 | PINA RECORDS |
| 27 | 11 | 9 | 6 | Your love is my drug | Ke$ha | 15 | 6 | SONY MUSIC |
| 28 | 38 | 27 | NI | Solo tuyo | Felipe Pelaez | 3 | 27 | SONY MUSIC |
| 29 | 16 | 19 | 18 | Fugidinha | Michel Teló | 5 | 16 | INDEPENDIENTE |
| 30 | 40 | NI | Dynamite | Taio Cruz | 2 | 30 | UNIVERSAL |
| 31 | 30 | 26 | 15 | Soy feliz | Ricardo Montaner | 10 | 15 | EMI |
| 32 | 18 | 17 | 19 | 24 horas | David Bisbal | 5 | 17 | UNIVERSAL |
| 33 | RI | 29 | 35 | El malo | Aventura | 5 | 23 | PREMIUN LATIN MUSIC |
| 34 | 31 | NI | Estar contigo | Alex Ubago – Jorge Villamizar & Lena | 2 | 31 | WARNER |
| 35 | 37 | NI | Mi corazón se fue | Diego Torres | 2 | 35 | UNIVERSAL |
| 36 | 34 | NI | Never say never | Justin Bieber & Jaden Smith | 2 | 34 | UNIVERSAL |
| 37 | 33 | 37 | 38 | Estar enamorado | Golpe A Golpe | 4 | 33 | INDEPENDIENTE |
| 38 | NI | Y si te quedas que | Santiago Cruz | 1 | 38 | INDEPENDIENTE |
| 39 | NI | Tu misterioso alguien | Miranda | 1 | 39 | WARNER |
| 40 | NI | Dame de eso | A Punto Cinco | 1 | 40 | INDEPENDIENTE |
| | | | SALIERON | | | | |
| 29 | 36 | 28 | Nubes negras | Jean Carlos Centeno | 11 | 18 | SONY MUSIC |
| 35 | 34 | 34 | Break your heart | Taio Cruz Feat. Ludracris | 18 | 9 | UNIVERSAL |
| 36 | 33 | 27 | Gettin’ over you | David Guetta Feat. Chris Willis | 14 | 18 | EMI |
| 39 | 38 | RI | El bla bla bla | El Potro Alvares Feat. Chino & Nacho | 3 | 38 | INDEPENDIENTE |
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| | | | LA GRAN CAÍDA | | 2S | HACE 2 SEMANAS |
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| EL GRAN SALTO | | 3S | HACE 3 SEMANAS |
| | | | MÁS SEMANAS EN LISTA | | SS | SEMANAS EN LISTA |
| | | | INGRESO MAS ALTO | | PA | POSICIÓN MAS ALTA |
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| | | RI | REINGRESO | | |
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| | | NI | NUEVO INGRESO | | |
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