| TOP LATINO SEMANA 21 – 2010 |
| ES | SA | 2S | 3S | Canción | Artista | SS | PA | Distribuidor |
| 1 | 9 | 4 | 4 | Gipsy (Gitana) | Shakira | 10 | 1 | SONY MUSIC |
| 2 | 1 | 1 | 1 | Mientes | Camila | 21 | 1(6) | SONY MUSIC |
| 3 | 3 | 5 | 7 | Telephone | Lady Gaga Feat. Beyoncé | 8 | 3 | UNIVERSAL |
| 4 | 4 | 7 | 9 | El doctorado | Tony Dize | 20 | 4 | PINA RECORDS |
| 5 | 5 | 9 | 14 | Baby | Justin Bieber & Ludacris | 6 | 5 | UNIVERSAL |
| 6 | 6 | 3 | 3 | Tik tok | Ke$ha | 18 | 2 | SONY MUSIC |
| 7 | 8 | 14 | 17 | Guapa | Diego Torres | 8 | 7 | UNIVERSAL |
| 8 | 14 | 18 | 21 | Egoista | Belinda & Pitbull | 7 | 8 | EMI |
| 9 | 7 | 10 | 10 | Niña bonita | Chino & Nacho Feat. Richie Peña | 46 | 7 | INDEPENDIENTE |
| 10 | 2 | 2 | 2 | Bad romance | Lady Gaga | 22 | 1(2) | UNIVERSAL |
| 11 | 19 | 19 | 18 | Estuve a punto de… | Miguel Bosé | 9 | 11 | WARNER |
| 12 | 18 | 23 | 16 | Te pido perdon | Tito El Bambino | 13 | 12 | UNIVERSAL |
| 13 | NI | | | Aléjate de mi | Camila | 1 | 13 | SONY MUSIC |
| 14 | 12 | 11 | 15 | Rude boy | Rihanna | 4 | 11 | UNIVERSAL |
| 15 | 11 | 16 | 12 | Hasta abajo | Don Omar | 17 | 10 | UNIVERSAL |
| 16 | 13 | 13 | 13 | Bien o mal | Julieta Venegas | 11 | 12 | SONY MUSIC |
| 17 | 10 | 6 | 6 | Meet me halfway | Black Eyed Peas | 23 | 5 | UNIVERSAL |
| 18 | 15 | 12 | 11 | Desde cuando | Alejandro Sanz | 17 | 7 | WARNER |
| 19 | RI | 17 | RI | Lo que no sabes tu | Chino & Nacho Feat. El Potro Alvares & Baroni | 13 | 17 | UNIVERSAL |
| 20 | 16 | 8 | 5 | Colgando en tus manos | Carlos Baute & Marta Sánchez | 58 | 1 | WARNER |
| 21 | 24 | 30 | 30 | Que sera de ti | Thalía | 5 | 21 | SONY MUSIC |
| 22 | 22 | 21 | 23 | Te siento | Wisin & Yandel | 8 | 21 | UNIVERSAL |
| 23 | 28 | 24 | 20 | Mi princesa | David Bisbal | 10 | 17 | UNIVERSAL |
| 24 | 26 | NI | | Noites de um Verão Qualquer | Skank | 2 | 24 | SONY MUSIC |
| 25 | 20 | 20 | 19 | Dile al amor | Aventura | 16 | 13 | PREMIUM LATIN |
| 26 | 36 | 40 | 24 | Yo no se mañana | Luis Enrique | 39 | 9 | INDEPENDIENTE |
| 27 | 23 | 25 | RI | Waving flag | K´naan & David Bisbal | 6 | 23 | UNIVERSAL |
| 28 | 25 | NI | | Yo te vi | Los Gigantes Del Vallenato | 2 | 25 | SONY MUSIC |
| 29 | NI | | | Dime que me amas | Banda El Recodo | 1 | 29 | INDEPENDIENTE |
| 30 | 27 | 26 | 34 | Naturally | Selena Gomez | 7 | 26 | HOLLYWOOD RECORDS |
| 31 | 39 | 39 | 40 | The only exception | Paramore | 5 | 31 | WARNER |
| 32 | NI | | | Rock that body | Black Eyed Peas | 1 | 32 | UNIVERSAL |
| 33 | 38 | 37 | 37 | Descontrol | Daddy Yankee | 6 | 32 | SONY MUSIC |
| 34 | 30 | 29 | 25 | Who l am | Nick Jonas & The Administration | 10 | 25 | UNIVERSAL |
| 35 | 21 | 15 | 8 | Me Enamoré de Ti | Chayanne | 24 | 4 | SONY MUSIC |
| 36 | NI | | | Me vas a recordar | Servando & Florentino | 1 | 36 | UNIVERSAL |
| 37 | 33 | 27 | 36 | Las mariposas | Penchy Castro | 5 | 27 | SONY MUSIC |
| 38 | 34 | 28 | 27 | El run run | Estopa & Rosario | 8 | 27 | SONY MUSIC |
| 39 | NI | | | Levo comigo | Restart | 1 | 39 | RADAR |
| 40 | 17 | NI | | No importa que el sol se muera | Moenia & Maria José | 2 | 17 | WARNER |
| | | | SALIERON | | | | |
| 29 | 34 | 38 | Frente a frente | Enrique Bunbury | 4 | 29 | EMI |
| 31 | NI | | Break your heart | Taio Cruz Feat. Ludracris | 1 | 31 | UNIVERSAL |
| 32 | NI | | Somos mas | Vos Veis | 1 | 32 | UNIVERSAL |
| 35 | 22 | 22 | Pode ir embora | Bruno & Marrone | 8 | 20 | SONY MUSIC |
| 37 | 38 | NI | Nadie te amara como yo | DYLAND & LENNY FT. ARCANGEL & ZION | 2 | 37 | SONY MUSIC |
| 40 | RI | 39 | Shut it down | Pitbull Feat. Akon | 2 | 39 | INDEPENDIENTE |
| |
| | ESTRENO MUNDIAL | | | | |
| | | | Inevitable | Dulce María | | | |
| | | | | | | | |
| | | | | Entrevista: Moenia | | | |
|
|
| | LA GRAN CAÍDA | | 3S | HACE 3 SEMANAS |
|
|
|
| EL GRAN SALTO | | SS | SEMANAS EN LISTA |
|
|
| | MÁS SEMANAS EN LISTA | | PA | POSICIÓN MAS ALTA |
| |
| | INGRESO MAS ALTO | | | | |
| | | | | |
|
| |
| | | RI | REINGRESO | |
|
| |
| | | NI | NUEVO INGRESO | |
|
| |
